منابع مشابه
Genetic Analysis of Complex Diseases
Neil Risch, in a series of seminal papers in 1990 (1, 2), demonstrated the utility of sibpair linkage analysis in identifying genes for complex genetic traits. In doing so, he defined what is the current paradigm for the genetic dissection of common complex genetic diseases. The recent Perspective by Risch and Kathleen Merikangas (3) again shapes the future of human disease gene mapping by defi...
متن کاملGenetic analysis of complex diseases.
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متن کاملSteps in Genetic Research of Complex Disease
Many of our most common diseases are complex disorders, run in families, but they lack the simple inheritance patterns characteristics of single gene disorders. Complex diseases have low heritability compared to single gene disorders. Understanding the genetic factors underlying common disorders is a difficult but critical task because each genetic and environmental factor can contribute toward...
متن کاملGenetic Analysis of Autoimmune Disease
so that parental chromosomes often bear different *Division of Basic Sciences National Jewish Center for Respiratory Medicine alleles allowing fully informative tracking of chromosomes from parents to affected progeny. Microsatellites and Immunology 1400 Jackson Street are flanked by unique sequences to which polymerase chain reaction primers can be designed, and many as-Denver, Colorado 80206 ...
متن کاملGenetic risk prediction in complex disease
Attempting to classify patients into high or low risk for disease onset or outcomes is one of the cornerstones of epidemiology. For some (but by no means all) diseases, clinically usable risk prediction can be performed using classical risk factors such as body mass index, lipid levels, smoking status, family history and, under certain circumstances, genetics (e.g. BRCA1/2 in breast cancer). Th...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 1995
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng0195-13